Ceruloplasmin (CP) is a metalloprotein with enzymatic activity, capable of transporting 95% of plasma copper. It is also involved in iron metabolism. Its ferroxidase function enables the inactivation of free radicals and other markers of oxidative stress, and it is considered an emerging biomarker of inflammatory processes. Thus, elevated serum PC levels are associated with acute coronary syndrome and neoplastic diseases. Knowledge of its molecular structure has made it possible to distinguish different ligand binding sites. These are related to the multiplicity of functions it can exert according to the biological context in which it is present, which is why it is called moonlighting protein. In the particular case of absence or genetic deficiency of CP, iron deposition was observed in the brain, liver, pancreatic tissue, etc. Regarding its therapeutic usefulness, it has been proposed as a target molecule in different types of cancers.